Supervisor
Research Interests: Cardiac Arrest, Education, Mental Health, Metabolism, Obstetrics & Gynaecology, Patient Safety.
Methodological Expertise: Interventional, Observational, Review, Statistics.
Qualifications:
BSc. Paramedicine; BSc.(hons) Bioanalysis; PhD (2011); Grad Cert HPE
Publications
2020 Publications (x 3)
1. Walz N.L., Hinchliffe P.M., Soares M.J., Dhaliwal S.S., Yovich J.L. & Keane K.N. Serum vitamin D status is associated with increased blastocyst development rate in women undergoing IVF. Reproductive Biomedicine Online, 41(6), 1101-11.
2. Rowles J.E., Keane K.N. et al. Are heat shock proteins an important link between type 2 diabetes and Alzheimer’s disease. International Journal of Molecular Sciences, 21(21), 1-20.
3. Yovich J.L., Mariappen U., Hinchliffe P.M., Dhaliwal S.S. & Keane K.N. MPA given orally during first trimester for threatened miscarriage carries no specific risk for foetal abnormalities albeit the rate is higher than non-threatened pregnancies. Reproductive Biology, 20(3), 424-32.
2019 Publications (x 8)
1. Yovich J.L., Ye Y., Reagan S.L.P. & Keane K.N. The evolving concept of poor-prognosis for women undertaking IVF and the notion of growth hormone as an adjuvant: A single-centre viewpoint. Frontiers in Endocrinology, 10, 808.
2. Keane K.N., Ye Y., Hinchliffe P.M., Regan S.L.P., Dhaliwal S.S. & Yovich J.L. Live birth outcomes of vitrified embryos generated under growth hormone stimulation are improved for women categorised as poor-prognosis. Clinical & Experimental Reproductive Medicine, 46(4), 178-88.
3. Ipsa E., Cruzat V., Kagize J.N., Yovich J.L & Keane K.N. Growth hormone and insulin-like growth factor action in reproductive tissues. Frontiers in Endocrinology, 10, 777.
4. Yovich J.L., Ye Y., Reagan S.L.P. Zaidi S. & Keane K.N. The concept of growth hormone deficiency affecting clinical prognosis in IVF. Frontiers in Endocrinology, 10, 650.
5. Yovich J.L., Ye Y. & Keane K.N. Growth hormone adjuvant trial for poor responders undergoing IVF. European Journal of Obstetrics and Gynecology and Reproductive Biology, 263, 249.
6. Keane K.N., Carlessi R. & Cruzat V. Oxidative stress pathways in pancreatic b-cells and insulin-sensitive cells and tissues: Importance to cell metabolism, function and dysfunction. American Journal of Physiology, 317(3), C420-33.
7. Kostrycki I.M., Wildner G., Donato Y.H., dos Santos A.B., Beber L.C.C., Frizzo M.N, Ludwig M.S., Keane K.N., Cruzat V., Rhoden C.R. & Heck T.G. Effects of high-fat diet on eHSP72 and extra-to-intracellular HSP70 levels in mice submitted to exercise under exposure to fine particulate matter. Journal of Diabetes Research, 2019, 4858740.
8. Rowlands J., Walz N. Rowles J.E., Keane K.N. et al. Method protocols for metabolic and functional analysis of the BRIN-BD11 b-cell line: A preclinical model for type 2 diabetes. Methods in Molecular Biology, 1916, 329-40.
2018 Publications (x 9) - 0.8 FTE
1. Cruzat V.C., Rogero M.M., Keane K.N. et al. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients, 10(11), 1564.
2. Visweswaran M., Keane K.N. et al. The influence of breast tumour-derived factors and wnt antagonism on the transformation of adipose-derived mesenchymal stem cells into tumour-associated fibroblasts. Cancer Microenvironment, 11(1), 71-84.
3. Keane K.N., Hinchliffe P.M., Rowlands P.K., Bourde G., Srinivasan S., Dhaliwal S.S. & Yovich J.L. DHEA supplementation confers no additional benefit to that of growth hormone on pregnancy and live birth rates in IVF patients catergorised as poor prognosis. Frontiers in Endocrinology, 9(14).
4. Yovich J.L., Chapman M., Keane K.N. & Savulescu J. Response: Risk of non-lethal abnormalities should not prevent pregnancies in women of advanced maternal age. Reproductive Biomedicine Online, Letter to the Editor, 37(5), 650.
5. Mariappen U., Keane K.N., Hinchliffe P.M., Dhaliwal S.S. & Yovich J.L. Neither male age nor semen parameters influence clinical pregnancy or live birth rates from IVF. Reproductive Biology, 18(4), 324-29.
6. Yovich J.L., Conceicao J.L., Marjanovich N., Ye Y., Hinchliffe P.M., Dhaliwal S.S. & Keane K.N. An ICSI rate of 90% prevents complete failed fertilisation and provides satisfactory implantation rates without elevating foetal abnormalities. Reproductive Biology, 18(3), 301-11.
7. Yovich J.L., Chapman M., Keane K.N. & Savulescu J. Is age 45 years the cut-off for using autologous oocytes. Reproductive Biomedicine Online, Editorial, 37(2), 1235-25.
8. McGonigle T.A., Dwyer A., Greenland E.L., Scott N.M. Carter K.W., Keane K.N. et al. Reticulon-1 and reduced migration towards chemoattractants by macrophages differentiated from the bone marrow of UV-irradiated and UV-chimeric mice. Journal of Immunology, 200(1), 260-70.
9. Yovich J.L., Keane K.N., Borude, G, Dhaliwal S.S. & Hinchliffe P.M. Finding a place for corifollitropin within the PIVET rFSH dosing algorithms. Reproductive Biomedicine Online, 36(1), 47-58.
2017 Publications (x 13)
1. Keane K.N. et al. The bioenergetics of inflammation: Insights into obesity and type 2 diabetes. European Journal of Clinical Nutrition, 71(7), 904-12.
2. *Carlessi R., *Keane K.N. et al. Nutrient regulation of b-cell function: What islets cells/animal studies tell us? European Journal of Clinical Nutrition, 71(7), 890-95.
3. Calton E.K., Keane K.N. et al. Winter to summer change in vitamin d status reduces systemic inflammation and bioenergetic activity of human peripheral blood mononuclear cells. Redox Biology, 12(2017), 814-20.
4. Calton E.K., Keane K.N. et al. The impact of cholecalciferol supplementation on systemic inflammatory profiles in humans: A systematic review of randomized controlled trials. European Journal of Clinical Nutrition, 71(8), 931-43.
5. Pathak K., Calton E., Soares M., Zhao Y., James A., Keane K.N. et al. Forearm to finger-tip skin temperature gradients in the thermoneutral zone were significantly related to resting metabolic rate: Potential implications for nutrition research. European Journal of Clinical Nutrition, 71(9), 1074-79.
6. McGonigle T.A., Dwyer A., Greenland E.L., Scott N.M., Keane K.N. et al. PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. Experimental Hematology, 56, 64-8.
7. McGonigle T.A., Keane K.N. et al. UV Irradiation of skin enhances glycolytic flux & reduces migration capabilities in bone marrow-differentiated dendritic cells. American Journal of Pathology, 187(9), 2046-59.
8. Carlessi R., Chen Y., Rowlands R., Cruzat V.F., Keane K.N. et al. GLP-1 receptor signalling promotes b-cell glucose metabolism via mTOR-dependent HIF-1-alpha activation. Scientific Reports, 7(1), 2661.
9. Keane K.N., Yovich J.L., Hamidi A., Hinchliffe P.M. & Dhaliwal S.S. A single centre retrospective analysis of growth hormone supplementation in poor-prognosis IVF patients. British Medical Journal Open, 7(10), e018107.
10. Yovich J.L. & Keane K.N. Assessing the male in fertility clinics – men undervalued, undermanaged and undertreated. Translational Andrology and Urology, 6(suppl 4), s624-s628.
11. Keane K.N. et al. Specific ranges of serum anti-Mullerian hormone correlate with antral follicle count and may provide a prognostic indicator of ovarian reserve and IVF outcome. Reproductive Biology, 17(1), 51-9.
12. *Mustafa K.B., *Keane K.N., Walz N., Mitrovic K., Hinchliffe P. & Yovich J.L. Live birth rates following multiple IVF treatment cycles in poor prognosis patients. Reproductive Biology, 17(1), 34-41.
13. Keane K.N. et al. Molecular actions of vitamin d in reproductive cell biology. Reproduction, 153(1), R29-42.
2016 Publications (x 8)
1. Cruzat V.F., Keane K.N. et al. Molecular mechanisms of ROS production and oxidative stress in diabetes. Biochemical Journal, 473(24), 4527-50.
2. Calton E.K., Keane K.N. et al. Prevailing vitamin D status influences mitochondrial and glycolytic bioenergetics in peripheral blood mononuclear cells obtained from adults. Redox Biology, 10, 243-50.
3. Calton E.K., Pathak K., Soares M.J., Helman A., Keane K.N. et al. Vitamin D status and insulin sensitivity are novel predictors of resting metabolic rate: A cross sectional analysis in Australian adults. European Journal of Nutrition, 55(6), 2075-80.
4. Keane K.N., Elahy M. & Cruzat V. Arginine, Pancreatic b-Cell Function & Diabetes: Mechanisms of Stimulated Insulin Release and Pathways of Metabolism. Arginine in Clinical Nutrition, Book Chapter, p84-95.
5. *Perumal V., *Poll S., *Keane K.N. et al. Therapeutic approach to target mesothelioma cancer cell using the wnt antagonist, sfrp4: metabolic state of cancer cell. Experimental Cell Research, 341(2), 218-24.
6. Chen Y., Carlessi R., Walz N., Cruzat V., Keane K.N. et al. Pigment Epithelium-Derived factor regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line brin-bd11 and mouse islets. Molecular & Cellular Endocrinology, 426, 50-60.
7. Keane K.N., Mustafa K.B., Hinchliffe P., Conceicao J.L. & Yovich J.L. Higher b-HCG concentrations and higher birthweights ensue from single vitrified embryo transfer. Reproductive Biomedicine Online, 33(2), 149-60.
8. *Yovich J.L., Alsbjerg B., Conceicao J.L., Hinchliffe P. & *Keane K.N. PIVET rFSH dosing algorithms for individualised controlled ovarian stimulation enables optimised pregnancy productivity rates and avoidance of ovarian hyperstimulation syndrome, Drug Design Development & Therapy, 10, 2561-73.
2015 Publications (x 11)
1. Keane K.N. et al. The impact of cryopreservation on human peripheral blood leukocyte bioenergetics. Clinical Science, 128(10), 723-33.
2. *Verdile G., *Keane K.N. et al. Inflammation and oxidative stress: The molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease. Mediators of Inflammation, 2015, 105828.
3. Keane K.N. et al. Molecular events linking oxidative stress and inflammation to insulin resistance and β-cell dysfunction. Oxidative Medicine & Cellular Longevity, 181643.
4. Cruzat V., Keane K.N. et al. Alanyl glutamine improves pancreatic b-cell function following ex vivo inflammatory challenge. Journal of Endocrinology, 224(3), 261-71.
5. Keane K., Gaudel C., & McClenaghan N.H. (Dys)Regulation of insulin secretion by macronutrients. The Islets of Langerhans (2nd Ed), ISBN 978-94-007-6685-3, Book Chapter, p129-56.
6. Calton E.K., Keane K.N. & Soares M.J. The potential regulatory role of vitamin D in the bioenergetics of inflammation. Current Opinions in Clinical Nutrition & Metabolic Care, 18, 367-73.
7. Calton E.K., Keane K.N. et al. The impact of vitamin D levels on inflammatory status: A systematic review of immune cell studies. PLOS One, 10(11), e0141770.
8. Keane K.N., Hinchliffe P.M., Namdar N., Conceicao J.L. & Yovich J.L. Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of patients undergoing in vitro fertilisation. Drug Design, Development & Therapy, 9, 5569-78.
9. Firns S., Cruzat V.F., Keane K.N. et al. The effect of cigarette smoking, alcohol consumption and fruit and vegetable consumption on IVF outcomes: A review and presentation of original data. Reproductive Biology & Endocrinology, 13, 134.
10. Yovich J.L., Conceicao J.L., Hinchliffe P.M., & Keane K.N. Mid-luteal serum progesterone levels govern the implantation rates for frozen embryo transfers conducted under hormone replacement. Reproductive Biomedicine Online, 31(2), 180-91.
11. Yovich J.L., Conceicao J.L., Hinchliffe P.M., & Keane K.N. Which blastocysts should be considered for genetic screening Human Reproduction, 30 (7), 1743-44.
2014 Publications (x 3)
1. Cruzat V., Arfuso F. & Keane K. Nutrient regulation of insulin secretion and action. Journal of Endocrinology, 221(3), R105-20.
2. Keane K. et al. Metabolic regulation of insulin secretion. Vitamins and Hormones, The Pancreatic Beta Cell, 95, 1-33.
3. Krause M., Keane K. et al.. Elevated levels of extracellular heat shock protein 72 (ehsp72) are positively correlated with insulin resistance in vivo & cause pancreatic b-cell dysfunction & death In Vitro. Clinical Science, 126(10), 739-52.
2007-2013 Publications (x 3)
1. Keane K., Homem de Bittencourt Jr. P.I., Murphy C. & Krause M. The impact of inflammation on pancreatic b-cell metabolism, function and failure in T1DM and T2DM: Commonalities and differences. Type 1 Diabetes (1st Ed), 2013, ISBN 980-953-307-711-1, Book Chapter.
2. Rathod D., Warren S., Keane K., Egan D.A. & Dempsey E. Evaluation of a modified carbon micromesh electrode as a new substrate for electrochemical immunosensing. Analytical Methods, 2011, 3, 799-805.
3. Curran R., Lenehan J., McCann M., Kavanagh K., Devereux M., Egan D.A., Clifford G., Keane K., Creaven B.S. & McKee V. [Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH = 9-anthracenecarboxylic acid): synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities. Inorganic Chemistry Communications, 2007, 10(10), 1149-1153.
